LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
XIST | miR-449a | Bcl-2 | BCL2;Bcl-2;PPP1R50 | details
HIF-1 signaling pathway;NF-kappa B signaling pathway;Protein processing in endoplasmic reticulum;Pathways in cancer;Small cell lung cancer;Prostate cancer;PI3K-Akt signaling pathway;Apoptosis;Focal adhesion; Neurotrophin signaling pathway;Cholinergic synapse;Amyotrophic lateral sclerosis (ALS);Colorectal cancer;Hepatitis B;Epstein-Barr virus infection; Toxoplasmosis;Tuberculosis
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We further identified reciprocal repression between XIST and miR-449a, which eventually influenced the expression of Bcl-2: XIST functioned as a miRNA sponge of miR-449a, which was a negative regulator of Bcl-2.
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The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancerThis article has been corrected since Advanced Online Publication, and an erratum is also printed in this issue.
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Non-small cell lung cancer | Acta Pharmacol Sin | 28248928 |