LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
CCR49 | let-7 | c-Myc | MYC;MRTL;MYCC;bHLHe39;c-Myc | details
Hepatitis B;MAPK signaling pathway;ErbB signaling pathway;Cell cycle;PI3K-Akt signaling pathway;Transcriptional misregulation in cancer;Bladder cancer;Wnt signaling pathway;Colorectal cancer;Endometrial cancer;Acute myeloid leukemia;TGF-beta signaling pathway;Hippo signaling pathway;Small cell lung cancer;Proteoglycans in cancer;Thyroid cancer;Jak-STAT signaling pathway;Pathways in cancer;HTLV-I infection;Chronic myeloid leukemia;Epstein-Barr virus infection
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details
Mechanistically, CCR492 functions as a competing endogenous RNA (ceRNA) to antagonize the function of let-7 microRNAs, leading to the de-repression of c-Myc.
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The long intergenic non-coding RNA CCR492 functions as a let-7 competitive endogenous RNA to regulate c-Myc expression
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Mouse Embryonic Fibroblasts | Biochim Biophys Acta | 27344374 |