| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| hsa_circ_0013958 | miR-134 | cyclin D1 | CCND1；BCL1；D11S287E；PRAD1；U21B31 | details | details
The results showed that hsa_circ_0013958 promoted cell proliferation and invasion and inhibited cell apoptosis in LAC. Moreover, hsa_circ_0013958 was identified as a sponge of miR-134, and thus it up-regulated oncogenic cyclin D1, which plays a pivotal role in the development of non-small cell lung cancer.
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details
hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma.
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Lung adenocarcinoma | FEBS J | 28685964 |
| hsa_circ_0012673 | miR-22 | ErbB3 | ERBB3；ErbB-3；HER3；LCCS2；MDA-BF-1；c-erbB-3；c-erbB3；erbB3-S；p180-ErbB3；p45-sErbB3；p85-sErbB3 | details
ErbB signaling pathway；Calcium signaling pathway；Endocytosis；Proteoglycans in cancer
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details
Furthermore, hsa_circ_0012673 was primarily localized in the cytoplasm and promoted cell proliferation of LAC cells by sponging miR-22, which targeted erb-b2 receptor tyrosine kinase 3 (ErbB3) in LAC. Hsa_circ_0012673 promotes LAC proliferation by suppressing miR-22, which targets ErbB3.
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details
Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation
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Lung adenocarcinoma | Biochem Biophys Res Commun | 29366790 |