Transcriptional misregulation in cancer

This epigenetic silencing of miR-218 by CCAT1 induces an altered cell cycle transition through BMI1 and provides a new mechanism for CSE-induced lung carcinogenesis.

Epigenetic silencing of miR-218 by the lncRNA CCAT1, acting via BMI1, promotes an altered cell cycle transition in the malignant transformation of HBE cells induced by cigarette smoke extract

Mineral absorption

NEAT1 may act as a competing endogenous lncRNA to upregulate EGCG-induced CTR1 by sponging hsa-mir-98-5p in NSCLC.

NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells

In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206. Re-expression of miR-206 reversed the RMRP-induced the H1299 cell proliferation and migration.

LncRNA-RMRP Acts as an Oncogene in Lung Cancer

Natural killer cell mediated cytotoxicity；MAPK signaling pathway；ErbB signaling pathway；Chemokine signaling pathway；PI3K-Akt signaling pathway；Insulin signaling pathway；Hepatitis C；Long-term potentiation；Progesterone-mediated oocyte maturation；Dorso-ventral axis formation；Axon guidance；Endometrial cancer；Regulation of actin cytoskeleton；VEGF signaling pathway；Long-term depression；Estrogen signaling pathway；Cholinergic synapse；Melanogenesis；Hepatitis B；Viral carcinogenesis；Tight junction；Neurotrophin signaling pathway；GnRH signaling pathway；Gap junction；Glioma；T cell receptor signaling pathway； Alcoholism；Prostate cancer；Serotonergic synapse；Bladder cancer；Non-small cell lung cancer；Chronic myeloid leukemia；HTLV-I infection；B cell receptor signaling pathway；Pathways in cancer；Aldosterone-regulated sodium reabsorption；Colorectal cancer；Melanoma；Acute myeloid leukemia；Proteoglycans in cancer；Pancreatic cancer；Renal cell carcinoma；Thyroid cancer；Fc epsilon RI signaling pathway

In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206. Re-expression of miR-206 reversed the RMRP-induced the H1299 cell proliferation and migration.

LncRNA-RMRP Acts as an Oncogene in Lung Cancer

MRAK088388 and MRAK081523 could regulate N4bp2 and Plxna4 expression by sponging miR-29b-3p and let-7i-5p, respectively, and possessed regulatory functions as ceRNAs.

Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis

MRAK088388 and MRAK081523 could regulate N4bp2 and Plxna4 expression by sponging miR-29b-3p and let-7i-5p, respectively, and possessed regulatory functions as ceRNAs.

Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis

In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206. Re-expression of miR-206 reversed the RMRP-induced the H1299 cell proliferation and migration.

LncRNA-RMRP Acts as an Oncogene in Lung Cancer