The function of linc-ROR exerted in LAD cells depended on the sponging of miR-145, therefore, releasing the miR-145 target FSCN1, and thus contributing to the acquisition of chemoresistance and EMT phenotypes of docetaxel-resistant LAD cells.

Long noncoding RNA ROR regulates chemoresistance in docetaxel-resistant lung adenocarcinoma cells via epithelial mesenchymal transition pathway

Hippo signaling pathway；Adherens junction

In particular, MALAT1 upregulated the expression of miR-204 target gene SLUG through competitively 'spongeing' miR-204.

LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204

TGF-beta signaling pathway； Estrogen signaling pathway；Huntington's disease；Transcriptional misregulation in cancer

Furthermore, we show that the long noncoding RNA HOTAIR repression reverses chemoresistance of LAD cells partially through modulation of miR-326/SP1 pathway.

miR-326 reverses chemoresistance in human lung adenocarcinoma cells by targeting specificity protein 1