Hedgehog signaling pathway；Pathways in cancer；Proteoglycans in cancer；Basal cell carcinoma

PTCH1 demethylation caused by miR-152 was responsible for the effects of PVT1 knockdown on PTCH1 expression.

Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152

p53 signaling pathway；Inositol phosphate metabolism；Prostate cancer；Phosphatidylinositol signaling system；mTOR signaling pathway；PI3K-Akt signaling pathway；Focal adhesion；Tight junction；Hepatitis B；Pathways in cancer；Melanoma；Endometrial cancer；Glioma；Small cell lung cancer

The effects of lincRNA-p21 on PTEN expression and HSC activation were inhibited by miR-181b mimics. We demonstrated that lincRNA-p21 enhanced PTEN expression by competitively binding miR-181b.

Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis

Axon guidance；MAPK signaling pathway；Chemokine signaling pathway；Natural killer cell mediated cytotoxicity；Fc epsilon RI signaling pathway；B cell receptor signaling pathway；Phagosome；PI3K-Akt signaling pathway；Pancreatic cancer；Wnt signaling pathway；Leukocyte transendothelial migration；Amyotrophic lateral sclerosis (ALS)；VEGF signaling pathway；Regulation of actin cytoskeleton；Proteoglycans in cancer；Epithelial cell signaling in Helicobacter pylori infection；Osteoclast differentiation；Shigellosis；Focal adhesion；Adherens junction；Neurotrophin signaling pathway；Salmonella infection；Renal cell carcinoma；Viral myocarditis；Pancreatic secretion；Pathways in cancer；Colorectal cancer；Toll-like receptor signaling pathway；Fc gamma R-mediated phagocytosis；Bacterial invasion of epithelial cells；Viral carcinogenesis

Luciferase reporter assay indicated that MALAT1 and RAS-related C3 botulinum substrate 1 (Rac1) are targets of miR-101b. We uncovered that MALAT1 regulates Rac1 expression through miR-101b as a competing endogenous RNA (ceRNA), thereby influencing the proliferation, cell cycle and activation of primary HSCs.

MALAT1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis