Dopaminergic synapse；PI3K-Akt signaling pathway；HTLV-I infection；Huntington's disease；Hepatitis B；Osteoclast differentiation；Antigen processing and presentation；Circadian rhythm；Alcoholism；Circadian entrainment；Cholinergic synapse；Prostate cancer；Viral carcinogenesis；Cocaine addiction；Tuberculosis；Insulin secretion；Estrogen signaling pathway；Melanogenesis；Amphetamine addiction；Vasopressin-regulated water reabsorption

Furthermore, we demonstrated HULC may act as an endogenous 'sponge', which down-regulates a series of microRNAs (miRNAs) activities, including miR-372. Inhibition of miR-372 leads to reducing translational repression of its target gene, PRKACB, which in turn induces phosphorylation of CREB.

CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer

HTLV-I infection；Cell cycle；Hepatitis B；Non-small cell lung cancer；Pathways in cancer；Pancreatic cancer；Glioma；Prostate cancer；Melanoma；Bladder cancer；Chronic myeloid leukemia；Small cell lung cancer

HULC increased the expression of E2F1 in hepatoma cells and levels of HULC were positively correlated with those of E2F1 in HCC tissues. Intriguingly, HULC sequestered miR-107, which targeted E2F1 mRNA 3'UTR, by complementary base pairing.

Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)

Sphingolipid metabolism；Metabolic pathways；Calcium signaling pathway；VEGF signaling pathway；Fc gamma R-mediated phagocytosis；Tuberculosis

Taken together, we conclude that HULC promotes tumor angiogenesis in liver cancer through miR-107/E2F1/SPHK1 signaling. Our finding provides new insights into the mechanism of tumor angiogenesis.

Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)