LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
COL1A2-AS1 | miR-21 | Smad7 | SMAD7;CRCS3;MADH7;MADH8 | details
Endocytosis;TGF-beta signaling pathway;Hippo signaling pathway
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Furthermore, we found that miR-21 was involved in lncRNA COL1A2-AS1-induced expression of Smad7, by which COL1A2-AS1 acted as endogenous sponge to adsorb miR-21 and in turn regulated Smad7 and a cascade of molecular to play a protective role in hypertrophic scar.
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LncRNA COL1A2-AS1 inhibits the scar fibroblasts proliferation via regulating miR-21/Smad7 pathway
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Hypertrophic scar tissue and fibroblasts | Biochem Biophys Res Commun | 29117538 |