LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
TUG1 | miR-300 | TGF-beta1 | TGFB1;CED;DPD1;LAP;TGFB;TGFbeta | details
Hippo signaling pathway;MAPK signaling pathway;Cytokine-cytokine receptor interaction;Cell cycle;Endocytosis;TGF-beta signaling pathway;Renal cell carcinoma;Hypertrophic cardiomyopathy (HCM);Chronic myeloid leukemia;Toxoplasmosis;Pathways in cancer;Osteoclast differentiation;HTLV-I infection;Proteoglycans in cancer;Intestinal immune network for IgA production;Rheumatoid arthritis;Dilated cardiomyopathy;Hepatitis B;Pancreatic cancer;Leishmaniasis;Tuberculosis;Chagas disease (American trypanosomiasis);Colorectal cancer; Malaria
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Mechanically, we found that TUG1 is upregulated by TGF-β1, and knockdown of TUG1 inhibited GBC cell EMT. Furthermore, we identified that miR-300, which has been reported as a suppressor in other types of cancer, is negatively regulated by TUG1.
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Long non-coding RNA TUG1 promotes cell proliferation and metastasis by negatively regulating miR-300 in gallbladder carcinoma
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Gallbladder Carcinoma | Biomed Pharmacother | 28178615 |