Cysteine and methionine metabolism；Metabolic pathways

H19 act as an endogenous sponge by directly binding to miR-152. miR-152 directly targeted DNMT1 and was regulated by H19. Besides, H19 overexpression dramatically relieved the inhibition of miR-152 on DNMT1 expression. miR-152 inhibition and DNMT1 overexpression obviously reversed the inhibitory effects of H19 downregulation on cell proliferation and invasion.

Long non-coding RNA H19 promotes the proliferation and invasion of breast cancer through upregulating DNMT1 expression by sponging miR-152.

Cytokine-cytokine receptor interaction；Endocytosis；PI3K-Akt signaling pathway；Axon guidance；Focal adhesion；Adherens junction；Bacterial invasion of epithelial cells；Proteoglycans in cancer；Renal cell carcinoma；Melanoma；Epithelial cell signaling in Helicobacter pylori infection；Malaria；Pathways in cancer；Transcriptional misregulation in cancer

We isolated cells from the primary mammary tumor, the circulation, and metastatic lesions in the lung in TA2 mice and found that the long noncoding RNA (lncRNA) H19 mediated EMT and MET by differentially acting as a sponge for the microRNAs miR-200b/c and let-7b.

The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b.

Cytokine-cytokine receptor interaction；Endocytosis；PI3K-Akt signaling pathway；Axon guidance；Focal adhesion；Adherens junction；Bacterial invasion of epithelial cells；Proteoglycans in cancer；Renal cell carcinoma；Melanoma；Epithelial cell signaling in Helicobacter pylori infection；Malaria；Pathways in cancer；Transcriptional misregulation in cancer

We isolated cells from the primary mammary tumor, the circulation, and metastatic lesions in the lung in TA2 mice and found that the long noncoding RNA (lncRNA) H19 mediated EMT and MET by differentially acting as a sponge for the microRNAs miR-200b/c and let-7b.

The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b.

Cytokine-cytokine receptor interaction；Endocytosis；PI3K-Akt signaling pathway；Axon guidance；Focal adhesion；Adherens junction；Bacterial invasion of epithelial cells；Proteoglycans in cancer；Renal cell carcinoma；Melanoma；Epithelial cell signaling in Helicobacter pylori infection；Malaria；Pathways in cancer；Transcriptional misregulation in cancer

We isolated cells from the primary mammary tumor, the circulation, and metastatic lesions in the lung in TA2 mice and found that the long noncoding RNA (lncRNA) H19 mediated EMT and MET by differentially acting as a sponge for the microRNAs miR-200b/c and let-7b.

The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b.