LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
TCONS_00075467 | miR-328 | CACNA1C | CACNA1C;CACH2;CACN2;CACNL1A1;CCHL1A1;CaV1.2;LQT8;TS | details
Long-term potentiation;MAPK signaling pathway;Calcium signaling pathway;Type II diabetes mellitus;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Cardiac muscle contraction;Vascular smooth muscle contraction;GnRH signaling pathway;Hypertrophic cardiomyopathy (HCM);Circadian entrainment;Retrograde endocannabinoid signaling; Dopaminergic synapse;Glutamatergic synapse;Alzheimer's disease;Cholinergic synapse;Serotonergic synapse;Insulin secretion;Dilated cardiomyopathy;Amphetamine addiction;GABAergic synapse
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Besides, the expression of miRNA-328 was negatively correlated with TCONS_00075467. We further demonstrated that TCONS_00075467 could sponge miRNA-328 in vitro and in vivo to regulate the downstream protein coding gene CACNA1C. In addition, miRNA-328 could partly reverse the effects of TCONS_00075467 on electrical remodeling.
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Altered long non-coding RNA expression profile in rabbit atria with atrial fibrillation: TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C.
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Atrial fibrillation | J Mol Cell Cardiol | 28546098 |