LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
CCAT1 | miR-155 | c-Myc | MYC;MRTL;MYCC;bHLHe39;c-Myc | details
Hepatitis B;MAPK signaling pathway;ErbB signaling pathway;Cell cycle;PI3K-Akt signaling pathway;Transcriptional misregulation in cancer;Bladder cancer;Wnt signaling pathway;Colorectal cancer;Endometrial cancer;Acute myeloid leukemia;TGF-beta signaling pathway;Hippo signaling pathway;Small cell lung cancer;Proteoglycans in cancer;Thyroid cancer;Jak-STAT signaling pathway;Pathways in cancer;HTLV-I infection;Chronic myeloid leukemia;Epstein-Barr virus infection
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Furthermore, CCAT1 could up-regulated c-Myc via its competing endogenous RNA (ceRNA) activity on miR-155.
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Long Non-Coding RNA CCAT1 Acts as a Competing Endogenous RNA to Regulate Cell Growth and Differentiation in Acute Myeloid Leukemia
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Acute Myeloid Leukemia | Mol Cells | 26923190 |
linc-223 | miR-125-5p | IRF4 | IRF4;LSIRF;MUM1;NF-EM5;SHEP8 | details | details
In particular, we show that linc-223 directly binds to miR-125-5p and that its knockdown increases the repressing activity of miR-125-5p resulting in the downregulation of its target interferon regulatory factor 4 (IRF4), which it was previously shown to inhibit the oncogenic activity of miR-125-5p in vivo.
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The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA
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Acute Myeloid Leukemia | Oncotarget | 27517498 |