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Insecticide Resistance Associated Gene Sequences Download

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#	Species	Target Genes				Detoxification Genes
#	Species	AChE	VGSC	RyR	nAChR	P450	GST	CCE
1	Acromyrmex echinatior	AChE	VGSC	RyR	nAChR	96	21	11
2	Acyrthosiphon pisum	AChE	VGSC	RyR	nAChR	103	26	8
3	Aedes aegypti	AChE	VGSC	RyR	nAChR	169	50	21
4	Aedes albopictus	AChE	VGSC	RyR	nAChR	313	67	29
5	Agrilus planipennis		VGSC	RyR	nAChR	112	15	36
6	Amyelois transitella		VGSC		nAChR	116	31	16
7	Anopheles coluzzii	AChE				88	32	13
8	Anopheles darlingi	AChE				94	23	18
9	Anopheles gambiae	AChE	VGSC		nAChR	117	36	42
10	Anopheles stephensi	AChE				98	37	18
11	Anoplophora glabripennis		VGSC	RyR	nAChR	158	42	69
12	Aphis gossypii	AChE	VGSC	RyR	nAChR	65	10	2
13	Apis dorsata	AChE	VGSC	RyR	nAChR	55	10	6
14	Apis florea	AChE	VGSC	RyR	nAChR	47	9	6
15	Apis mellifera	AChE	VGSC	RyR	nAChR	80	12	8
16	Apolygus lucorum		VGSC			21	3	2
17	Athalia rosae	AChE	VGSC	RyR	nAChR	95	26	8
18	Bactrocera cucurbitae	AChE	VGSC	RyR	nAChR	120	38	12
19	Bactrocera dorsalis	AChE	VGSC	RyR	nAChR	102	39	9
20	Bactrocera oleae	AChE	VGSC	RyR	nAChR	108	39	8
21	Bemisia tabaci	AChE	VGSC	RyR	nAChR	195	26	14
22	Blattella germanica	AChE	VGSC			12	5
23	Bombus impatiens	AChE	VGSC	RyR	nAChR	62	24	7
24	Bombus terrestris	AChE	VGSC	RyR	nAChR	77	23	7
25	Bombyx mandarina	AChE	VGSC	RyR	nAChR	89	21	17
26	Bombyx mori	AChE	VGSC	RyR	nAChR	126	34	14
27	Camponotus floridanus	AChE	VGSC	RyR	nAChR	271	22	6
28	Cephus cinctus		VGSC	RyR	nAChR	116	13	14
29	Cerapachys biroi	AChE	VGSC	RyR	nAChR	106	12	14
30	Ceratitis capitata	AChE	VGSC	RyR	nAChR	122	42	11
31	Ceratosolen solmsi marchali		VGSC	RyR	nAChR	47	9	4
32	Chilo suppressalis	AChE		RyR	nAChR	77	19	37
33	Cimex lectularius	AChE	VGSC	RyR	nAChR	96	19	15
34	Cnaphalocrocis medinalis	AChE	VGSC	RyR		41	25	37
35	Ctenocephalides felis	AChE	VGSC	RyR	nAChR	121	19	15
36	Culex quinquefasciatus	AChE	VGSC	RyR		201	23	25
37	Cydia pomonella	AChE			nAChR	98	16	4
38	Dendroctonus ponderosae	AChE	VGSC	RyR	nAChR	138	35	19
39	Diaphorina citri		VGSC		nAChR	105	31	6
40	Diuraphis noxia			RyR	nAChR	69	10	5
41	Drosophila busckii		VGSC	RyR	nAChR	90	33	9
42	Drosophila erecta	AChE	VGSC	RyR	nAChR	99	39	8
43	Drosophila melanogaster	AChE	VGSC	RyR	nAChR	115	57
44	Drosophila obscura		VGSC	RyR	nAChR	108	39	11
45	Drosophila persimilis	AChE	VGSC	RyR	nAChR	93	38	6
46	Drosophila suzukii		VGSC	RyR	nAChR	117	46	6
47	Drosophila willistoni	AChE	VGSC	RyR	nAChR	103	36	19
48	Fopius arisanus	AChE	VGSC	RyR	nAChR	75	16	8
49	Frankliniella occidentalis		VGSC	RyR	nAChR	111	31	23
50	Halyomorpha halys		VGSC	RyR	nAChR	184	31	36
51	Harpegnathos saltator	AChE		RyR	nAChR	164	26	12
52	Helicoverpa armigera	AChE	VGSC	RyR	nAChR	117	56	17
53	Leptinotarsa decemlineata	AChE	VGSC	RyR	nAChR	109	28	45
54	Locusta migratoria				nAChR	18	34	40
55	Lucilia cuprina	AChE		RyR	nAChR	96	30	19
56	Manduca sexta	AChE			nAChR	27	4
57	Megachile rotundata	AChE	VGSC	RyR	nAChR	86	20	6
58	Microplitis demolitor	AChE	VGSC	RyR	nAChR	54	18	6
59	Musca domestica	AChE	VGSC	RyR	nAChR	184	43	16
60	Myzus persicae	AChE	VGSC	RyR	nAChR	81	27	6
61	Nasonia vitripennis	AChE	VGSC	RyR	nAChR	168	28	46
62	Nicrophorus vespilloides		VGSC	RyR	nAChR	149	22	22
63	Nilaparvata lugens	AChE	VGSC	RyR	nAChR	88	17	23
64	Orussus abietinus		VGSC	RyR	nAChR	49	22	5
65	Ostrinia furnacalis		VGSC	RyR	nAChR	101	33	21
66	Papilio xuthus		VGSC	RyR	nAChR	104	28	13
67	Pediculus humanus corporis	AChE	VGSC	RyR		38	5	1
68	Pieris rapae		VGSC	RyR	nAChR	86	25	20
69	Plutella xylostella	AChE	VGSC	RyR	nAChR	100	29	12
70	Pogonomyrmex barbatus		VGSC	RyR	nAChR	89	24	5
71	Polistes canadensis		VGSC	RyR	nAChR	78	16	4
72	Polistes dominula		VGSC	RyR	nAChR	116	18	7
73	Pseudomyrmex gracilis		VGSC	RyR	nAChR	188	10	7
74	Solenopsis invicta		VGSC	RyR	nAChR	253	20	9
75	Spodoptera exigua		VGSC	RyR	nAChR	80	2	1
76	Spodoptera litura		VGSC	RyR	nAChR	131	41	22
77	Stomoxys calcitrans	AChE	VGSC	RyR	nAChR	261	65	28
78	Trachymyrmex septentrionalis			RyR	nAChR	84	23	8
79	Tribolium castaneum	AChE	VGSC	RyR	nAChR	156	41	17
80	Trichogramma pretiosum		VGSC	RyR	nAChR	79	18	14
81	Vollenhovia emeryi	AChE	VGSC	RyR	nAChR	213	16	10
82	Wasmannia auropunctata	AChE	VGSC	RyR	nAChR	291	39	16

AChE : AChE (acetylcholinesterase) is the biological target of organophosphates and carbamates. During neurotransmission, AChE terminates the signal transmission by hydrolyzing ACh. ACh is released from the pre-synaptic neuron into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane.
VGSC : VGSC (voltage-gated sodium channel) is the biological target of pyrethroids and DDT. In excitable cells such as neurons, myocytes, and certain types of glia, VGSCs are responsible for the rising phase of action potentials and guarantee the regular stimulus transmission.
RyR : RyR (ryanodine receptor) is the biological target of anthranilic diamide insecticides. RyRs are important in neurons and muscle cells. It mediates the release of calcium ions from the sarcoplasmic reticulum and endoplasmic reticulum and is involved in signal pathway.
nAChR : nAChR (nicotinic acetylcholine receptor) is the biological target of neonicotinoid insecticides. It serves as the receptor of neurotransmitters and play an important role in neurotransmission.

Detoxification Genes : three detoxification gene families are associated with insecticide resistance,P450(cytoehrome P450); GST (glutathione S-transferase); and CCE(carboxyl/cholinesterase).