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Ortholog

Group-ID iGroup-00182[Fasta]
Gene Name DNA topoisomerase
Group Bombyx mori: BGIBMGA003151-PA
Danaus plexippus: DPOGS211165-PA
Linepithema humile: LH22610-PA
Nasonia vitripennis: NV11433-PA
Tribolium castaneum: TCOGS2:TC010428-PA
Aedes aegypti: AAEL002551-PA
Pediculus humanus: PHUM395750-PA
Bombyx mori|BGIBMGA003151-PADanaus plexippus|DPOGS211165-PAAedes aegypti|AAEL002551-PALinepithema humile|LH22610-PANasonia vitripennis|NV11433-PATribolium castaneum|TCOGS2 TC010428-PAPediculus humanus|PHUM395750-PA

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					CLUSTAL 2.1 multiple sequence alignment


Linepithema_humile|LH22610-PA       --------------------------------------------------
Nasonia_vitripennis|NV11433-PA      MEIEQPVPRADVDLEKKAKENSSAAGNHGDAQMNGMTNGYDHKKEHKSEH
Tribolium_castaneum|TCOGS2_TC0      MEVENGANGEDSSPSHKMKEYNSDT-----AQVNGIN-GYSDKKSHKSEH
Pediculus_humanus|PHUM395750-P      --MMNNNNNNNNFFLNKTSLYVLEN----TTLVNGISNGYNKDHKSEHKH
Bombyx_mori|BGIBMGA003151-PA        MSVENPASDN-DCESGKVNG-NKNEH------VNGMHNGYS------SSD
Danaus_plexippus|DPOGS211165-P      MSVENPASD--DGDSGKVNG-NKSEH------VNGIQNGYS------SSE
Aedes_aegypti|AAEL002551-PA         MSVEVEAANPQDNSTKQVNGESASDR------PNGVSNGHSEGGGGGSSD
                                                                                      

Linepithema_humile|LH22610-PA       --------------------------------------------------
Nasonia_vitripennis|NV11433-PA      RDKDKERSH-KSEHKDKEKS------------HKSEHRDKDRHKHSSSSS
Tribolium_castaneum|TCOGS2_TC0      KDKHRDKDRERDKEKSKSKE------------HKSS-KDKDRHS-SSSKD
Pediculus_humanus|PHUM395750-P      RDREKEKHR-SDKYKHKHSS------------SKSSHKDKERDS------
Bombyx_mori|BGIBMGA003151-PA        KHKSSHKSSSKDKHRDKDRD------------------------------
Danaus_plexippus|DPOGS211165-P      KHKSSHKSSSKDKHRDKERD------------------------------
Aedes_aegypti|AAEL002551-PA         DRRKSHKSSSKDKHRDKDRDRDREKDKSRSDKDRDRDKDKERSKDKDRDR
                                                                                      

Linepithema_humile|LH22610-PA       --------------------------------------------------
Nasonia_vitripennis|NV11433-PA      KDKDKDKHSSSKDKEKDKDRSRDKDKKSSSSSSKDKEHKSSSSSSRDKEK
Tribolium_castaneum|TCOGS2_TC0      KDRDKERHSSHKSSSRDKERS-DKDKHRD----KDK-HRDEKKSSKDKEK
Pediculus_humanus|PHUM395750-P      -EKEKKLVDDKKSHEKDKERRSSPSNKDSKSSSKDKHHSSSSSSSSSKDK
Bombyx_mori|BGIBMGA003151-PA        --HKGSSKHSSSSRDKDKDKHSSSKE-------HSSSHKSSS-KDKEHNS
Danaus_plexippus|DPOGS211165-P      --HKSSKHSSSSSRDKDKDRHSSNKN-------HSSSHKSSS-RDKERDR
Aedes_aegypti|AAEL002551-PA         DKHKSSSSSSSKDKDRDKDKSSSSSSKDKDRDRHSSSHKSSR-SDKDREK
                                                                                      

Linepithema_humile|LH22610-PA       --------------------------------------------------
Nasonia_vitripennis|NV11433-PA      DKERSKDKEHHKSSSSSSSKDKHHSSSSKDKDKEKDKERSKDKDKHKDRH
Tribolium_castaneum|TCOGS2_TC0      EHKSSHDKDHKSSSKDKERKDKDKHSSSKDKDK--------------DRH
Pediculus_humanus|PHUM395750-P      DKDR-----HGSSHRDKDKHGTSSSSSSSSSKK--------------DRH
Bombyx_mori|BGIBMGA003151-PA        EKRDRSDKDHSSR-DKERS-DKDK--HRSDKDK--------------HRE
Danaus_plexippus|DPOGS211165-P      EHRDDKHKDRERS-DRERS-DKDRDRHKSDKDR--------------HRE
Aedes_aegypti|AAEL002551-PA         DKERSKDKDKERSKDKDRERDKDKE-RSKDKDR--------------ERD
                                                                                      

Linepithema_humile|LH22610-PA       --------------------------------------------------
Nasonia_vitripennis|NV11433-PA      SSSQSSSRDKDKEKSSKDK---KHSSEKDKDRHSSSHSSEKDKQRSSDKE
Tribolium_castaneum|TCOGS2_TC0      SSSKDKHRDKDK----------HHSSSKDKDRK------DKNKERKSEKE
Pediculus_humanus|PHUM395750-P      SS-QSKEKDKHHISSS------TTSSSSSKERYNSSSSKDKDKHKDKEKE
Bombyx_mori|BGIBMGA003151-PA        KSKKE---------------------------------------------
Danaus_plexippus|DPOGS211165-P      RSEKDKDRSEKDKHKSSNGEK-KSSKEHSSSSRDKDKSKDTDKHRDHDKD
Aedes_aegypti|AAEL002551-PA         KDRKDRDKDKSSSSSSKDKDRDKHKSSSSSSSRDKDKERDKEKSKSSSSS
                                                                                      

Linepithema_humile|LH22610-PA       --------------------------------------------------
Nasonia_vitripennis|NV11433-PA      KHSSSEKDKDRHRHDKDRDRHRHDKEKSKHRDEKERKEKNREESKSKDEN
Tribolium_castaneum|TCOGS2_TC0      ----SEKSYDD-------EREKKSKNHSKHENDVGREDSAREDSVDEDDN
Pediculus_humanus|PHUM395750-P      SHDKSKDSKER-------SKDRGDSRDSKREREKEKEKEKVSSDKNSDQE
Bombyx_mori|BGIBMGA003151-PA        --------------------------------------------------
Danaus_plexippus|DPOGS211165-P      RSYKEKHRSDKDRHSSSKEKHSSSKSKEKSSSEKNDKVKLEEEYRDSSMK
Aedes_aegypti|AAEL002551-PA         SKDKDKHSSSSSSKDKDRKDRSDKHSSSKDKDRERKEEKVKEEPAEVKQE
                                                                                      

Linepithema_humile|LH22610-PA       --------------------------------------------------
Nasonia_vitripennis|NV11433-PA      KVKEDVKVEPEIKTKIKMEQESFKEHEEDYDSGDDNQRLYIKEEDEEMKQ
Tribolium_castaneum|TCOGS2_TC0      ------------KLIIKEEPESQDEVDD-------------KNASAASSC
Pediculus_humanus|PHUM395750-P      -----------LKEIKDENMPEFKTYTG-------------DSADNTGDS
Bombyx_mori|BGIBMGA003151-PA        --------------------------------------------------
Danaus_plexippus|DPOGS211165-P      QEYMEVDEPTVKREMKSESDDGYGGALN----------------TTVSSC
Aedes_aegypti|AAEL002551-PA         QQEVKHEEPSAMFNGVASNESSQDVSEIKQEDP--------LSISQASSC
                                                                                      

Linepithema_humile|LH22610-PA       -----------------------------------------------MIL
Nasonia_vitripennis|NV11433-PA      DNSMDSTDANDTRL-----------SDMHNTTVKT----EEDESDEDMPL
Tribolium_castaneum|TCOGS2_TC0      DYNLSQFKSDESRF-----------EDS-TADVKQ----EED-SDEDLPL
Pediculus_humanus|PHUM395750-P      APEEESLRIDEDRD-----------ENQQEVKIKEEKEEEEEGVESDVPL
Bombyx_mori|BGIBMGA003151-PA        --------------------------------------------------
Danaus_plexippus|DPOGS211165-P      DYSLSQF-------------------KDEPLSEMPLEEDSASGGEEDVPL
Aedes_aegypti|AAEL002551-PA         DYSMSQFRADESQFVIKEEASDQDQAEEEPEEPTPMEVKQESDSEDDVPL
                                                                                      

Linepithema_humile|LH22610-PA       MLR-----------LKRKYFT-------VVYSLQKPKK------------
Nasonia_vitripennis|NV11433-PA      ASRSSGISP----GVKRKVETSDEDDDIPLSARKKPKKE-----------
Tribolium_castaneum|TCOGS2_TC0      SARMEHTS------VKRKIESDDEDD-MPLNARKKPKKE-----------
Pediculus_humanus|PHUM395750-P      SMRVPKRE------IEGDNDDDDDDDETPLFARLKKKIKQEDSDDDFKPG
Bombyx_mori|BGIBMGA003151-PA        --------------------------------------------------
Danaus_plexippus|DPOGS211165-P      LERK----------AIKKRAISESEEDTPLLQRKKQKKKV----------
Aedes_aegypti|AAEL002551-PA         SKRKKKDDDEDFDGGSKQKKIKTEKKDKKEKKKKKRAYES----------
                                                                                      

Linepithema_humile|LH22610-PA       --------------------------------------KNTKVKTEGGSP
Nasonia_vitripennis|NV11433-PA      PVAKKQKKKKK--------VESEDEEYDEPEEKPQKKRKPKAEKTENSSP
Tribolium_castaneum|TCOGS2_TC0      KKEKSEKKKKKR------SVEDDEEEWDRPVKKEKIKKEKDSIKTENESP
Pediculus_humanus|PHUM395750-P      KKTKGKKRKSKG------DSDSEDDFKPAAKKPSKTVIKKEVKKETTTSP
Bombyx_mori|BGIBMGA003151-PA        TYEDYDDYEED---------EKPKKKKKSSEKTKS-VKVKSEPIDDGISP
Danaus_plexippus|DPOGS211165-P      KKENYDDYDDE---------ESQQKKK--AKKTKS-TKSIKTEADDGPSP
Aedes_aegypti|AAEL002551-PA         EAEEFDEEEDEDYGAAKKKKQAKQVKKEVKKETKTKTKVKTEVKQETASP
                                                                                    **

Linepithema_humile|LH22610-PA       RK---KKQEDEQ-EVWKWYKDFIKWEEEKKSDGTKWNFLEHKGPVFAPPY
Nasonia_vitripennis|NV11433-PA      KK---KKKEEEEPEVWKW------WEEEKKNDGTKWHFLEHKGPVFAPEY
Tribolium_castaneum|TCOGS2_TC0      KKGGRKKKEEEPQEVWKW------WEEEKKDDGKKWKFLEHKGPVFAPPY
Pediculus_humanus|PHUM395750-P      KK---VKKEEEQQDVWKW------WEEEKREDGKKWKFLEHKGPLFAPLY
Bombyx_mori|BGIBMGA003151-PA        NKR-KKKQDTETEQVWKW------WEEEKTDDGTKWTFLEHKGPVFAPPY
Danaus_plexippus|DPOGS211165-P      TKR-KKK-ENEEQEVWKW------WEESKTDDGTKWHFLEHKGPLFAPLY
Aedes_aegypti|AAEL002551-PA         TKG-RKKKQEEEEEVWKW------WEEEKREDGVKWNTLEHKGPVFAPPY
                                     *    * : *  :****      ***.* .** **  ******:*** *

Linepithema_humile|LH22610-PA       EPLPPTVKFYYNGKEMKLSQDTEEVATFYARMLDHDYTTKPAFNSNFFQD
Nasonia_vitripennis|NV11433-PA      EPLPPSVKFYYNGKEMKLTQDTEEVATFYARMLEHDYTTKQVFNDNFFHD
Tribolium_castaneum|TCOGS2_TC0      EPLPDHVKFYYDGKEMKLTPEAEEVASFYSKMLDHDYTTKEVFNNNFFKD
Pediculus_humanus|PHUM395750-P      ERLPKSVKFFYDGKEISLSEEAEEVATFYAKMLTHDYTTKEKFNTNFFND
Bombyx_mori|BGIBMGA003151-PA        EPLPSNVKFYYDGKELN-----------YLKMLK----------------
Danaus_plexippus|DPOGS211165-P      EPLPENVKFRYDGKIVRLSQDSEEVAGFYARMLDHDYTTKTVFNTNFFND
Aedes_aegypti|AAEL002551-PA         EPLPDNVKFEYDGKVIKLSQDAEEIAGFYARMLEHEYTSKDAFNDNFFKD
                                    * **  *** *:** :            * :**                 

Linepithema_humile|LH22610-PA       WRDVMTESERAKIIDLSKCNFKDIHSYFLQKSEERKAMTKEEKQKIKEKN
Nasonia_vitripennis|NV11433-PA      WREVMTESERAKITDLKKCNFTEMHKYFIMKSEERKAMSKEEKKAIKEKN
Tribolium_castaneum|TCOGS2_TC0      WRKVMSESERKVIKDLKKCNFKSMHAYYMDLAEKNRNRTKEEKQALKEKN
Pediculus_humanus|PHUM395750-P      WRKVMTDKERKVITDLSKCNFKPMALYFQEKSEERKAMSKEEKKVIKDQN
Bombyx_mori|BGIBMGA003151-PA        -----------------------------------KNRSKEEKAALKAKN
Danaus_plexippus|DPOGS211165-P      WRKVMTNEEAKLIKDLSKCDFKEMQTYFQSVSEKNKNRSKEEKAALKAKN
Aedes_aegypti|AAEL002551-PA         WRKSMTSSEREKIKDLKKCNFRSMHKHFAEISEANRNRTKEQKLALKEQN
                                                                       :  :**:*  :* :*

Linepithema_humile|LH22610-PA       DEIQKEYGFCVIDGHKEKIGNFKIEPPGLFRGRGEHPKMGKLKKRVVPED
Nasonia_vitripennis|NV11433-PA      DEIQKEYGICTIDGHKEKIGNFKIEPPGLFRGRGEHPKMGKLKKRLVPED
Tribolium_castaneum|TCOGS2_TC0      EALIKEYGFCNIDGHKEKIGNFKIEPPGLFRGRGEHPKMGMLKRRVEAED
Pediculus_humanus|PHUM395750-P      DAIQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGMLKKRVLPED
Bombyx_mori|BGIBMGA003151-PA        EEIQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPED
Danaus_plexippus|DPOGS211165-P      EEIQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGMLKRRVMPED
Aedes_aegypti|AAEL002551-PA         EALMKEYGTCSIDGHKEKIGNFRIEPPGLFRGRGEHPKMGMVKRRVMPED
                                    : : **** * ***********:***************** :*:*: .**

Linepithema_humile|LH22610-PA       VLINCSKTSNIPKPPPGHKWKEIRHDPNVTWLASWTENIQGQVKYVMLNP
Nasonia_vitripennis|NV11433-PA      VLINCSKDSVHPKPPPGHKWKEIRHDPTVTWLASWTENIQGQVKYVMLNP
Tribolium_castaneum|TCOGS2_TC0      IIINCSQDSKIPEPPPGHKWKEVRHDDNVTWLASWTENVQNQVKYIMLNP
Pediculus_humanus|PHUM395750-P      VIINCSKDSKIPKPPDGHKWKKVQHDPSVTWLASWTENVQGNVKYVMLNP
Bombyx_mori|BGIBMGA003151-PA        VLINCSKDSKIPKPPSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNP
Danaus_plexippus|DPOGS211165-P      VIINCSKDSKIPKPPAGHKWKEVRHDNTVTWLASWTENVQQQAKYVMLNP
Aedes_aegypti|AAEL002551-PA         VIINCGKESVWPKAPEGHRWKEVRHDNSVSWLASWTENVQGQVKYVMLNP
                                    ::***.: *  *:.* **:*::::** .*:********:* :.**:****

Linepithema_humile|LH22610-PA       SSKLKGEKDWQKYETARKLAQSIDKIRAEYREDWKSKEMRIRQRAVALYF
Nasonia_vitripennis|NV11433-PA      SSKLKGEKDWQKYETARKLAKSVDKIRATYREDWKSKEMRIRQRAVALYF
Tribolium_castaneum|TCOGS2_TC0      SSKLKGEKDWQKYETARRLHKCIDKIREEYKDDWKSKEMRIRQRAVALYF
Pediculus_humanus|PHUM395750-P      SSKLKGEKDMVKYETARKLAKKIDKIREQYQADWKSKEMKIRQRAVALYF
Bombyx_mori|BGIBMGA003151-PA        SSKLKGEKDWQKYETARKLHKCIDKIRENYRADWKAKEMQVRQRAVALYF
Danaus_plexippus|DPOGS211165-P      SSKLKGEKDWQKYETARNLHKCIDKIRETYKSDWKAKEMRVRQRAVALYF
Aedes_aegypti|AAEL002551-PA         SSKLKGEKDWQKYETARRLLKHIDKIRDTYRDEWKSKEMRIRQRAVALYF
                                    *********  ******.* : :****  *: :**:***::*********

Linepithema_humile|LH22610-PA       IDKLALRAGNEKDEDQADTVGCCSLRVEHIQLHEHKDGREYVVVFDFLGK
Nasonia_vitripennis|NV11433-PA      IDKLALRAGNEKDEDQADTVGCCSLRVEHIALHEKKDGKEYVVVFDFLGK
Tribolium_castaneum|TCOGS2_TC0      IDKLALRAGNEKDEDQADTVGCCSLRVEHISLHKEKDGKEYVVVFDFLGK
Pediculus_humanus|PHUM395750-P      IDKLALRAGNEKDEDQADTVGCCSLRVEHVELYPELNGKENVVVFDFLGK
Bombyx_mori|BGIBMGA003151-PA        IDRLALRAGNEKDDEQADTVGCCSLRVEHIQLHKEKDGKEYVVVFDFLGK
Danaus_plexippus|DPOGS211165-P      IDRLALRAGNEKDDDQADTVGCCSLRVEHIELHKEKDGKEFVVVFDFLGK
Aedes_aegypti|AAEL002551-PA         IDKLALRAGNEKDEDQADTVGCCSLRVEHIDLHKELNGKENVVVFDFLGK
                                    **:**********::**************: *: . :*:* *********

Linepithema_humile|LH22610-PA       DSIRYYNEVPVEKRVFKNLQLFMENKSPGDDLFDRLNTTVMNKHLNELME
Nasonia_vitripennis|NV11433-PA      DSIRYYNEVPVEKRVFKSLQLFMENKSPGDELFDRLNTTVMNKHLNELMD
Tribolium_castaneum|TCOGS2_TC0      DSIRYYNEVPVEKRVFKNLQLFMEHKSPGDDLFDRLNTAIMNKHLNELME
Pediculus_humanus|PHUM395750-P      DSIRYYNEVPVEKRVFKNLLLFKENKQPQDDLFDRLNTTVLNKHLNELME
Bombyx_mori|BGIBMGA003151-PA        DSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMP
Danaus_plexippus|DPOGS211165-P      DSIRYYNEVPVEKRVFKNLEIFMENKKDSDDLFDRLNTQTLNEHLKELMP
Aedes_aegypti|AAEL002551-PA         DSIRYYNEVEVEKRVFKNLELFKENKKPGDDLFDRLNTSVLNEHLRELME
                                    ********* *******.* :* *:*.  *:*******  :*:**.:** 

Linepithema_humile|LH22610-PA       GLTAKVFRTYNASWTLQQQLDKLTDPNDMEAEKILSYNRANRAVAILCNH
Nasonia_vitripennis|NV11433-PA      GLTAKVFRTYNASWTLQQQLEELTDPNSTVAEKILSYNRANRAVAILCNH
Tribolium_castaneum|TCOGS2_TC0      GLTAKVFRTYNASWTLQQQLDKLTNADDSVAEKILAYNRANRAVAILCNH
Pediculus_humanus|PHUM395750-P      GLTAKVFRTYNASWTLQEQLKELTNPDDTVAEKLLAYNRANRAVAILCNH
Bombyx_mori|BGIBMGA003151-PA        GLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNH
Danaus_plexippus|DPOGS211165-P      GLTAKVFRTYNASITLQRQLEELTDPDATIPEKILAYNRANRAVAILCNH
Aedes_aegypti|AAEL002551-PA         GLTAKVFRTFNASFTLQNQLRELTDPDMTVPEKLLAYNRANRAVAILCNH
                                    *********:*** ***.** :**: :   .**:*:**************

Linepithema_humile|LH22610-PA       QRSVPKTHAKSMENLKAKIEAKKEAIAECELQVKDAKRDAKHGSVKEKVT
Nasonia_vitripennis|NV11433-PA      QRSVPKSHEKSMENLKAKIDAKREAIAEAEQIVKDAKRDAKHGSVKEKVL
Tribolium_castaneum|TCOGS2_TC0      QRSVPKGHEKSMEKLKEKIDAKKEAIKDAERQVKDAAKDAKHGSVKEKTV
Pediculus_humanus|PHUM395750-P      QRSVPKSHEKSMENLKAKIEAKREQINEIKKEVKNAKRNGDSG------T
Bombyx_mori|BGIBMGA003151-PA        QRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAKRGSVKEKLA
Danaus_plexippus|DPOGS211165-P      QRAVPKGHSKSMEALKEKIQAKRDQVDEAEADYRDAAKAAKRGSVKEKLA
Aedes_aegypti|AAEL002551-PA         QRAVPKTHEKSMSNLKEKIRAKQEAVETCERELKDLKKSN----VRDKVA
                                    **:*** * ***. ** ** **:: :   :   ::  :            

Linepithema_humile|LH22610-PA       YDKKKKQLERLKEQLTKLEVQATDREENKEIALGTSKLNYLDPRISVAWC
Nasonia_vitripennis|NV11433-PA      YEKKKKQLDRLKEQLMKLEVQATDREENKEIALGTSKLNYLDPRISVAWC
Tribolium_castaneum|TCOGS2_TC0      YDKKKKMLQRLKEQLTKLEIQETDRDENKTIALGTSKLNYLDPRISVAWC
Pediculus_humanus|PHUM395750-P      EAKKKKQLDRLKEQLLKLEVQETDKEENKTIALGTSKLNYLDPRISVAWC
Bombyx_mori|BGIBMGA003151-PA        CDKKKKALERLKDQLKKLELQETDRDENKTIALGTSKLNYLDPRISVAWC
Danaus_plexippus|DPOGS211165-P      CDKKKKALERLKEQLKKLELQETDRDENKTIALGTSKLNYLDPRISVSWC
Aedes_aegypti|AAEL002551-PA         KDKKQKQLERLREQLNKLELQETDKDENKTIALGTSKLNYLDPRISVAWC
                                      **:* *:**::** ***:* **::*** *****************:**

Linepithema_humile|LH22610-PA       KKHNVPIEKIYNKTQRDKFRWAIDMAGPDYVF
Nasonia_vitripennis|NV11433-PA      KKHDVPIEKIYNKTQRDKFRWAIDMAGPDYVF
Tribolium_castaneum|TCOGS2_TC0      KKYGVPIEKIYNKTQRDKFRWAIDMAGPDYVF
Pediculus_humanus|PHUM395750-P      KKYNVPIEKIYNKTQRDKFRWAIDMAGPDYVF
Bombyx_mori|BGIBMGA003151-PA        KKHGVPIEKIYNKTQRDKFRWAIDMAGPDYVF
Danaus_plexippus|DPOGS211165-P      KKHGVPIEKIYNKTQRDKFRWAIDMAGPDYIF
Aedes_aegypti|AAEL002551-PA         KKFGVPIEKIFNKTQRDKFRWAIDMADENYIF
                                    **..******:***************. :*:*